Polynucleotides vs Profhilo: Which Injectable Skin Booster Is Right for You?
With the rise of non-surgical skin rejuvenation, many patients are exploring injectable skin boosters to improve skin quality, hydration, and radiance without adding volume. Two leading treatments in this category are Polynucleotides and Profhilo —but which is best for your skin?
At our Milton Keynes aesthetic clinic, we specialise in both Polynucleotide and Profhilo treatments, offering personalised plans for clients seeking natural, long-lasting results. In this blog, we explain the key differences to help you make an informed choice.
🧬 What Are Polynucleotides?
Polynucleotides are regenerative injectables made from highly purified DNA fragments (often salmon-derived). Unlike fillers that simply hydrate or add volume, polynucleotides work at a cellular level to stimulate tissue repair, collagen production, and cell renewal.
Benefits of Polynucleotides:
Reduces inflammation and redness (great for rosacea-prone skin)
Improves texture, elasticity, and tone
Supports healing in scarred or acne-prone skin
Revitalises delicate under-eye areas
Stimulates fibroblasts for long-term tissue repair
💧 What Is Profhilo?
Profhilo is a patented bio-remodelling injectable composed of pure hyaluronic acid (HA). It spreads beneath the skin like honey, stimulating hydration and mild collagen production without changing the shape of your face.
Benefits of Profhilo:
Intense, deep hydration boost
Improves skin laxity and firmness
Leaves skin plumper and more radiant
Quick 15-minute treatment with minimal downtime
Works well on face, neck, décolletage, and hands
💡Polynucleotides regenerate skin cells and repair damage, while Profhilo provides deep hydration and improves elasticity.
🔍 Key Differences: Polynucleotides vs Profhilo
While both Polynucleotides and Profhilo are injectable skin boosters, they work in very different ways and are suited to different skin concerns.
Polynucleotides use DNA fragments (typically derived from salmon) to promote deep tissue regeneration, cell renewal, and healing. This makes them particularly beneficial for clients dealing with acne scarring, inflammation, under-eye concerns, or early signs of ageing. Polynucleotides are injected into precise areas such as the face, under eyes, or neck, and usually require 3 to 4 sessions followed by occasional maintenance.
On the other hand, Profhilo is made entirely of pure hyaluronic acid and is designed to hydrate and firm the skin. It spreads evenly beneath the surface, making it ideal for clients seeking an overall glow, improved skin elasticity, and a subtle lift in areas like the face, neck, décolletage, and hands. The typical treatment course for Profhilo includes two sessions spaced one month apart, followed by top-up treatments every few months.
In short, Polynucleotides focus on skin regeneration and healing, while Profhilo provides deep hydration and bio-remodelling. The right choice depends on your individual concerns and goals—which we always evaluate during your consultation at our Milton Keynes clinic.
🧖♀️ Which Treatment Is Right for You?
Choose Polynucleotides if:
You’re concerned with scarring, under-eye hollowing, or inflammation
You want regeneration and repair, not just hydration
Choose Profhilo if:
You’re dealing with dull, dry, or crepey skin
You want a hydration-first solution with subtle lifting effects
At our clinic in Milton Keynes, we assess your skin and recommend the best approach—sometimes even combining both treatments for optimal results.
📍 Book Your Skin Booster Consultation in Milton Keynes
Whether you’re new to injectables or looking to upgrade your skin routine, Profhilo and Polynucleotides offer effective, natural-looking results. Book a consultation with our expert team today to discover which injectable is right for your skin concerns.